Arjun Reddy, a medico with anger management issues, gets into a brawl with another student and is asked to either apologize or leave college. Arjun prepares to leave but stays back after seeing a first year student, Preethi Shetty. Arjun, along with his friend Shiva, goes to first year class room and announces that he is in love with Preethi and she is exclusive to him. Preethi, although initially afraid of his nature, eventually reciprocates his feelings and their relationship grows stronger over the course of next 3 years. Preethi’s father rejects him on the grounds of caste and arranges her marriage with someone else. Arjun protests in front of her house and gets arrested. His father ostracizes him from home for damaging family reputation. He gets an apartment flat with the help of his friend Shiva and joins as a house surgeon in a leading hospital. Unable to forget her, he becomes alcoholic and drug addict. He befriends one of his patients and a leading film star, Jia Sharma, and asks her for a no strings relationship but eventually rejects her after she grows feelings for him. After collapsing in operation theater under the influence of alcohol and drugs, his medical license is temporarily canceled and he is evicted from his flat. Next morning, his grandmother dies and he reconciles his father to give up his self-destructive habits. While on vacation, he learns that Preethi is unhappy with her marriage and meets her after returning home. Arjun convinces Preethi, now a pregnant woman, to live with him. Preethi reveals that he is the father to the child and she left home after marriage and living alone ever since working in a clinic. They get married to each other.